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Title: Pyrogenic activity of human native and human recombinant interleukins-1beta: stabilization with albumin enhances the pyrogenic action of recombinant IL-1beta delivered into the rabbit brain
Authors: Lesnikov, V A ×
Efremov, O M
Simbirtsev, A S
Van Damme, Jozef
Billiau, Alfons #
Issue Date: Aug-1994
Series Title: The International Journal of Neuroscience vol:77 issue:3-4 pages:267-75
Abstract: The pyrogenic potential of natural and recombinant human IL-1 beta in rabbits was found to be very similar when the substances were given intravenously. Under these conditions, stabilization of rIL-1 beta with human serum albumin (HSA) failed to affect the pyrogenic activity of recombinant IL-1 beta. When the two preparations were administered directly into the PO/AH area of the brain, recombinant IL-1 beta was less pyrogenic than its natural counterpart. This lower pyrogenicity of recombinant IL-1 beta was corrected if the injected material contained HSA, which is known to stabilize in vitro the biological activities of IL-1 beta against slow degradation. The possibility is now considered that the central and peripheral systems for IL-1 inactivation are different. The existence of an intrabrain IL-1 pool is suggested and its significance for neuroimmunomodulation is stressed.
ISSN: 0020-7454
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Academic Center for General Practice
Laboratory of Molecular Immunology (Rega Institute)
Laboratory of Immunobiology (Rega Institute)
× corresponding author
# (joint) last author

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