Title: PRNP Val129 homozygosity increases risk for early-onset Alzheimer's disease
Authors: Dermaut, Bart
Croes, EA
Rademakers, R
Van den Broeck, M
Cruts, M
Hofman, A
van Duijn, CM
Van Broeckhoven, C # ×
Issue Date: Mar-2003
Publisher: Wiley-liss
Series Title: Annals of neurology vol:53 issue:3 pages:409-412
Abstract: We analyzed the PRNP M129V polymorphism in a Dutch population-based early-onset Alzheimer's disease sample. We observed a significant association between early-onset Alzheimer's disease and homozygosity of M129V (odds ratio [OR], 1.9; 95% confidence interval [CI], 1.1-3.3; P = 0.02) with the highest risk for V homozygotes (OR, 3.2; 95% CI, 1.4-7.1; p < 0.01). In patients with a positive family history, these risks increased to 2.6 (95% CI, 1.3-5.3; p < 0.01) and 3.5 (95% CI, 1.3-9.3; p = 0.01), respectively.
ISSN: 0364-5134
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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