Dose dependent effect of APOE epsilon 4 on behavioral symptoms in frontal lobe dementia
Engelborghs, S Dermaut, Bart Marien, P Symons, A Vloeberghs, E Maertens, K Somers, N Goeman, J Rademakers, R Van den Broeck, M Pickut, B Cruts, M Van Broeckhoven, C De Deyn, PP # ×
Elsevier science inc
Neurobiology of aging vol:27 issue:2 pages:285-292
To determine whether apolipoprotein alleles (APOE) influence behavioral and psychological signs and symptoms of dementia (BPSD), we initiated a prospective, longitudinal study. Patients with Alzheimer's disease (AD) (N = 186), frontotemporal dementia (FTD) (N=29), mixed dementia (MXD) (N= 28), dementia with Lewy bodies (DLB) (N= 11) and Parkinson's disease dementia (PDD) (N = 7) were included. Blood was collected for DNA extraction and APOE genotyping. Behavioral assessments were performed at baseline and semi-annually thereafter, using behavioral assessment scales (Middelheim frontality score, behavioral pathology in Alzheimer's disease rating scale (Behave-AD)).