Title: Dose dependent effect of APOE epsilon 4 on behavioral symptoms in frontal lobe dementia
Authors: Engelborghs, S
Dermaut, Bart
Marien, P
Symons, A
Vloeberghs, E
Maertens, K
Somers, N
Goeman, J
Rademakers, R
Van den Broeck, M
Pickut, B
Cruts, M
Van Broeckhoven, C
De Deyn, PP # ×
Issue Date: Feb-2006
Publisher: Elsevier science inc
Series Title: Neurobiology of aging vol:27 issue:2 pages:285-292
Abstract: To determine whether apolipoprotein alleles (APOE) influence behavioral and psychological signs and symptoms of dementia (BPSD), we initiated a prospective, longitudinal study. Patients with Alzheimer's disease (AD) (N = 186), frontotemporal dementia (FTD) (N=29), mixed dementia (MXD) (N= 28), dementia with Lewy bodies (DLB) (N= 11) and Parkinson's disease dementia (PDD) (N = 7) were included. Blood was collected for DNA extraction and APOE genotyping. Behavioral assessments were performed at baseline and semi-annually thereafter, using behavioral assessment scales (Middelheim frontality score, behavioral pathology in Alzheimer's disease rating scale (Behave-AD)).
ISSN: 0197-4580
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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