Octapeptide repeat insertions in the prion protein gene and early onset dementia
Croes, EA Theuns, J Houwing-Duistermaat, JJ Dermaut, Bart Sleegers, K Roks, G Van den Broeck, M van Harten, B van Swieten, JC Cruts, M Van Broeckhoven, C van Duijn, CM # ×
B m j publishing group
Journal of Neurology, Neurosurgery and Psychiatry vol:75 issue:8 pages:1166-1170
Objectives: The most common familial early onset dementia mutations are found in the genes involved in Alzheimer's disease; the amyloid precursor protein (APP) and the presenilin 1 and 2 (PSEN1 and 2) genes; the prion protein gene ( PRNP) may be involved.