Title: Tau is central in the genetic Alzheimer-frontotemporal dementia spectrum
Authors: Dermaut, Bart
Kumar-Singh, S
Rademakers, R
Theuns, J
Cruts, M
Van Broeckhoven, C # ×
Issue Date: Dec-2005
Publisher: Elsevier science london
Series Title: Trends in genetics vol:21 issue:12 pages:664-672
Abstract: In contrast to the common and genetically complex senile form of Alzheimer's disease (AD), the molecular genetic dissection of inherited presenile dementias has given important mechanistic insights into the pathogenesis of degenerative brain disease. Here, we focus on recent genotype-phenotype correlative studies in presenile AD and the frontotemporal dementia (FTD) complex of disorders. Together, these studies suggest that AD and FTD are linked in a genetic spectrum of presenile degenerative brain disorders in which tau appears to be the central player.
ISSN: 0168-9525
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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