Possible association of nicastrin polymorphisms and Alzheimer disease in the Finnish population
Helisalmi, S Dermaut, Bart Hiltunen, M Mannermaa, A Van den Broeck, M Lehtovirta, M Koivisto, AM Iivonen, S Cruts, M Soininen, H Van Broeckhoven, C # ×
Lippincott williams & wilkins
Neurology vol:63 issue:1 pages:173-175
The authors previously reported that genetic variation in the gene coding for nicastrin (NCSTN) modified risk for familial early-onset Alzheimer disease (AD) in a Dutch population-based sample. Risk was highest in patients without an APOE epsilon4 allele. Here, they evaluated if NCSTN polymorphisms increased risk of AD in the eastern Finnish population. A significant difference in one haplotype was observed in AD patients without the APOE epsilon4 allele.