Title: Amyloid beta secretase gene (BACE) is neither mutated in nor associated with early-onset Alzheimer's disease
Authors: Cruts, M ×
Dermaut, Bart
Rademakers, R
Roks, G
Van den Broeck, M
Munteanu, G
van Duijn, CM
Van Broeckhoven, CV #
Issue Date: Nov-2001
Publisher: Elsevier sci ireland ltd
Series Title: Neuroscience Letters vol:313 issue:1-2 pages:105-107
Abstract: The beta-site of beta -amyloid precursor protein cleaving enzyme (BACE) cleaves the beta -amyloid (AB) precursor protein at the N-terminal end of A beta, allowing for the production of A beta by C-terminal gamma -secretase cleavage. We hypothesized that over-activity of BACE might lead to the overproduction of A beta, hence causing Alzheimer's disease (AD). Molecular genetic analyses of BACE in 9 autosomal dominant AD families and a population-based sample of 101 presenile AD cases did not identify genetic linkage, pathogenic mutations or genetic association with BACE, suggesting that BACE is not genetically involved in the etiology of AD. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
ISSN: 0304-3940
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Associated Laboratories - miscellaneous (-)
× corresponding author
# (joint) last author

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