Title: Hen egg white lysozyme vaccination induces acute shock in NOD mice
Authors: Branisteanu, Dumitru *
Overbergh, Lutgart *
Decallonne, Brigitte *
Mathieu, Chantal # ×
Issue Date: Nov-2003
Series Title: Annals of the New York Academy of Sciences vol:1005 pages:215-7
Abstract: To investigate whether vaccination could induce lethal shock and which mechanisms are involved in this phenomenon, we tested a panel of autoantigens or diabetes-irrelevant peptides or proteins in nonobese diabetic (NOD), Balb/c, and C57Bl/6 mice. Of the antigens tested, only nondiabetogenic hen egg white lysozyme induced a severe form of shock exclusively in NOD mice. The mechanism involved is suggestive of a Th(2)-mediated anaphylactic reaction possibly connected to activation of PAF and triggering of DIC.
ISSN: 0077-8923
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical and Experimental Endocrinology
* (joint) first author
× corresponding author
# (joint) last author

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