Title: Nonclassical effects of 1alpha,25-dihydroxyvitamin D(3) and its analogs
Authors: Verstuyf, Annemieke ×
Verlinden, Lieve
Segaert, Siegfried
van Etten, Evelyne
Mathieu, Chantal
Bouillon, Roger #
Issue Date: Jul-1999
Publisher: S. Karger
Series Title: Mineral and Electrolyte Metabolism vol:25 issue:4-6 pages:345-8
Abstract: The activated form of vitamin D(3), 1alpha,25(OH)(2)D(3), not only plays a central role in bone and calcium metabolism but has also potent antiproliferative and prodifferentiating effects. Moreover, the combined presence of 25(OH)D(3)-1alpha-hydroxylase as well as the vitamin D receptor in several tissues introduced the idea of a paracrine role for 1alpha,25(OH)(2)D(3). By introducing chemical modifications into the flexible parent molecule 1alpha,25(OH)(2)D(3), a whole generation of vitamin D analogs was created. Due to a clear dissociation of the antiproliferative and prodifferentiating effects from calcemic effects, these analogs can be used not only for the treatment of bone disorders but also for non-classical applications.
ISSN: 0378-0392
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical and Experimental Endocrinology
Laboratory of Dermatology
Medical Clerkships Centers
Laboratory of Dermatoimmunology (+)
× corresponding author
# (joint) last author

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