Title: Bone morphogenetic protein signaling in the murine distraction osteogenesis model
Authors: Lammens, Johan ×
Liu, Zhendong
Luyten, Frank #
Issue Date: Feb-2009
Publisher: Acta Medica Belgica
Series Title: Acta Orthopaedica Belgica vol:75 issue:1 pages:94-102
Abstract: A murine distraction osteogenesis model was standardized to allow analysis of the molecular pathways associated with postnatal de novo bone formation. The authors examined the presence and expression of Bone Morphogenetic Proteins (BMPs) -2,-3,-4,-6 and -7, and the BMP receptors Alk3 and AM at different stages. Strong signals were detected for BMP-4 at the end of the distraction period and for BMP-6 during the entire experimental period. Signals for BMP-7 (Osteogenic Protein-1) were very low, suggesting a less important role during the normal process of distraction bone healing. Immunohistochemical staining revealed the presence of BMP-4 in the early chondroblasts, while BMP-6 was detected in the more mature cartilage cells. The data indicate a BMP molecular profile reminiscent of the embryonic maturation process in endochondral bone formation.
ISSN: 0001-6462
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Orthopaedics Section (-)
Rheumatology Section (-)
× corresponding author
# (joint) last author

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