Title: Cholecystokinin/gastrin signaling in nematodes: Evidence for evolutionary conservation in gastrointestinal endocrinology
Authors: Janssen, Tom
Meelkop, Ellen
Nachman, Ronald J.
Schoofs, Liliane #
Issue Date: 2008
Conference: Bioscenter Symposium on Genetic diversity in medicine, agriculture and conservation location:Leuven, Belgium date:September 2008
Abstract: Members of the cholecystokinin/gastrin family of peptides, including the arthropod sulfakinins, and their cognate receptors, play an important role in the regulation of feeding behavior and energy homeostasis. By using the potential C. elegans CCK receptors as bait, we have isolated and identified two CCK-like neuropeptides as the endogenous ligands of these nematode receptors. Both receptors and ligands share a high degree of sequence similarity with their vertebrate and arthropod counterparts and also display similar biological activities with respect to digestive enzyme secretion and fat storage. Our data indicate that the CCK/gastrin signaling system was already well established prior to the divergence of protostomes and deuterostomes.
Publication status: published
KU Leuven publication type: AMa
Appears in Collections:Animal Physiology and Neurobiology Section - miscellaneous
Department of Biology - miscellaneous
# (joint) last author

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