Title: Evolutionary conservation of the cholecystokinin/gastrin signaling system in nematodes
Authors: Janssen, Tom ×
Meelkop, Ellen
Nachman, Ronald J.
Schoofs, Liliane #
Issue Date: Apr-2009
Publisher: New York Academy of Sciences
Series Title: Annals of the New York Academy of Sciences vol:1163 pages:428-432
Abstract: Members of the cholecystokinin/gastrin family of peptides, including the arthropod sulfakinins, and their cognate receptors, play an important role in the regulation of feeding behavior and energy homeostasis. By using the potential C. elegans CCK receptors as bait, we have isolated and identified two CCK-like neuropeptides as the endogenous ligands of these nematode receptors. Both receptors and ligands share a high degree of sequence similarity with their vertebrate and arthropod counterparts and also display similar biological activities with respect to digestive enzyme secretion and fat storage. Our data indicate that the CCK/gastrin signaling system was already well established prior to the divergence of protostomes and deuterostomes.
ISSN: 0077-8923
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Animal Physiology and Neurobiology Section - miscellaneous
Department of Biology - miscellaneous
× corresponding author
# (joint) last author

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