Title: Synthesis and biological activity of 22-oxa CD-ring modified analogues of 1alpha,25-dihydroxyvitamin D3: spiro[5.5]undecane CF-ring analogues
Authors: Schepens, Wim ×
Van Haver, Dirk Van
Vandewalle, Maurits
De Clercq, Pierre J
Bouillon, Roger
Verstuyf, Annemieke #
Issue Date: Aug-2004
Series Title: Bioorganic & medicinal chemistry letters vol:14 issue:15 pages:3889-92
Abstract: The synthesis and biological activity of novel CD-ring modified analogues of 22-oxa-1alpha,25-dihydroxyvitamin D(3), lacking the D-ring and featuring a connection between C-18 and C-21 (spiro[5.5]undecane CF-ring analogues), is described. The central ring system is conveniently synthesised from an achiral intermediate. The analogues have marginal binding affinity for the nVDR and possess low to moderate genomic activity.
ISSN: 0960-894X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical and Experimental Endocrinology
× corresponding author
# (joint) last author

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