Monitoring levels of preservative sensitivity in Europe. A 10-year overview (1991-2000)
Wilkinson, J D × Shaw, S Andersen, K E Brandao, F M Bruynzeel, D P Bruze, M Camarasa, J M G Diepgen, T L Ducombs, G Frosch, P J Goossens, An Lachappelle, J-M Lahti, A Menné, T Seidenari, S Tosti, A Wahlberg, J E #
Contact dermatitis vol:46 issue:4 pages:207-10
A 10-year multicentre analysis of the frequency of sensitivity to common preservatives collected in 16 centres in 11 countries has shown stable but persisting high levels of sensitivity to formaldehyde and 5-chloro-2-methyl-4-isothiazolin-3-one + 2-methyl-4-isothiazolin-3-one (MCI/MI). It has also revealed a significant increase in the level of reactivity to methyldibromoglutaronitrile (MDBGN) from 0.7% in 1991 to 3.5% in 2000. The current high level of sensitivity to MDBGN requires an urgent safety re-evaluation and risk assessment update along with consideration of immediate lowering of use concentrations, especially in leave-on products.