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Title: Monitoring levels of preservative sensitivity in Europe. A 10-year overview (1991-2000)
Authors: Wilkinson, J D ×
Shaw, S
Andersen, K E
Brandao, F M
Bruynzeel, D P
Bruze, M
Camarasa, J M G
Diepgen, T L
Ducombs, G
Frosch, P J
Goossens, An
Lachappelle, J-M
Lahti, A
Menné, T
Seidenari, S
Tosti, A
Wahlberg, J E #
Issue Date: Apr-2002
Series Title: Contact dermatitis vol:46 issue:4 pages:207-10
Abstract: A 10-year multicentre analysis of the frequency of sensitivity to common preservatives collected in 16 centres in 11 countries has shown stable but persisting high levels of sensitivity to formaldehyde and 5-chloro-2-methyl-4-isothiazolin-3-one + 2-methyl-4-isothiazolin-3-one (MCI/MI). It has also revealed a significant increase in the level of reactivity to methyldibromoglutaronitrile (MDBGN) from 0.7% in 1991 to 3.5% in 2000. The current high level of sensitivity to MDBGN requires an urgent safety re-evaluation and risk assessment update along with consideration of immediate lowering of use concentrations, especially in leave-on products.
URI: 
ISSN: 0105-1873
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Dermatology
Laboratory of Dermatoimmunology (+)
× corresponding author
# (joint) last author

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