Title: Numerical simulation of bone regeneration in a bone chamber
Authors: Geris, Liesbet * ×
Vandamme, Katleen *
Naert, Ignace
Vander Sloten, Jos
Duyck, Joke
Van Oosterwyck, Hans #
Issue Date: Mar-2009
Publisher: Journal of Dental Research
Series Title: Journal of Dental Research vol:88 issue:2 pages:158-163
Abstract: While mathematical models are able to capture
essential aspects of biological processes like fracture
healing and distraction osteogenesis, their
predictive capacity in peri-implant osteogenesis
remains uninvestigated. We tested the hypothesis
that a mechano-regulatory model has the potential
to predict bone regeneration around implants. In
an in vivo bone chamber set-up allowing for controlled
implant loading (up to 90 μm axial displacement),
bone tissue formation was simulated
and compared qualitatively and quantitatively with
histology. Furthermore, the model was applied to
simulate excessive loading conditions. Corresponding
to literature data, implant displacement
magnitudes larger than 90 μm predicted the formation
of fibrous tissue encapsulation of the implant.
In contradiction to findings in orthopedic implant
osseointegration, implant displacement frequencies
higher than 1 Hz did not favor the formation
of peri-implant bone in the chamber. Additional
bone chamber experiments are needed to test these
numerical predictions.
Description: Statement of correction
ISSN: 0022-0345
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Prosthetics
Biomechanics Section
* (joint) first author
× corresponding author
# (joint) last author

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