Title: Radioimmunoassay for parathyrin. Characterization of six different antigens and antisera
Authors: Voll, R ×
Schmidt-Gayk, H
Wiedeman, J
Hüfner, M
Bouillon, Roger
Keutmann, H
Hehrmann, R #
Issue Date: May-1978
Publisher: de Gruyter
Series Title: Journal of clinical chemistry and clinical biochemistry vol:16 issue:5 pages:269-277
Abstract: We studied six different antisera to bovine or porcine parathyrin (parathyroid hormone, PTH), produced in rabbit, guinea pigs, sheep or goat, two of which are commercially available. The antisera were characterized with regard to species specificity, affinity and their ability to identify patients with primary hyperparathyroidism. In this heterologous radioimmunoassay system in which [125I]parathyrin is used as a tracer, some cross-reactivity of the antisera to the hormone or hormone fragments present in human serum was demonstrated. However, there is some overlap of serum immunoreactive parathyrin in patients with or without primary hyperparathyroidism. The results of this and other studies illustrate the necessity for a homologous radioimmunoassay for human parathyrin.
ISSN: 0340-076X
Publication status: published
KU Leuven publication type: DI
Appears in Collections:Clinical and Experimental Endocrinology
× corresponding author
# (joint) last author

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