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Title: Induction of immune reaction against rat embryonal carcinoma by activation of viral genome
Authors: Sobis, H ×
Van Hove, L
Heremans, Hubertine
De Ley, Marc
Billiau, Alfons
Vandeputte, Michel #
Issue Date: Jul-1980
Series Title: International Journal of Cancer vol:26 issue:1 pages:93-9
Abstract: A cell line (F3/1) derived from a rat embryonal carcinoma, originally induced in fetectomized rats injected with MSV, was found to be essentially non-immunogenic in a syngeneic host; the cells did not produce C-type virions. The MSV genome could be rescued by superinfection of F3/1 cells with endogenous C-type mouse virus and the cells were converted in a producer line-F3/1-P. The produced virus was shown to be MSV by its ability to induce focus formation in mouse fibroblasts. In contrast to its non-producer ancestor, the F3/1-P line proved to be strongly immunogenic in the syngeneic host. These results indicate the possibility of converting certain non-immunogenic tumors into immunogenic ones by the activation of dormant viral genome using xenogeneic non-oncogenic helper virus.
ISSN: 0020-7136
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Immunobiology (Rega Institute)
× corresponding author
# (joint) last author

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