Title: A view on beta cell transplantation in diabetes
Authors: Pipeleers, Daniel ×
Keymeulen, Bart
Chatenoud, Lucienne
Hendrieckx, Christel
Ling, Zhidong
Mathieu, Chantal
Roep, Bart
Ysebaert, Dirk #
Issue Date: Apr-2002
Series Title: Annals of the New York Academy of Sciences vol:958 pages:69-76
Abstract: Organ donors also offer a source of insulin-producing tissue that might be used for the treatment of diabetes. Clinical protocols for transplantation of this tissue aim for the prevention of chronic diabetes complications without introducing new serious side effects. Pancreas and islet cell transplantation are discussed in this perspective. The future of islet cell implants looks favorable but depends on finding ways to induce immune tolerance to the donor beta cells. Clinical trials can take advantage of relevant progress in animal models. In a limited study, recipient treatment with antilymphocyte antibodies and culture of donor cell preparations appeared useful to induce a state of operational immune tolerance in type 1 diabetic patients, as indirectly judged by graft survival and by analysis of auto- and alloreactivities in recipients. Use of cultured beta cell preparations also allows donor cell recruitment from suboptimal donor organs and increases the degree of standardization and quality control of islet cell grafts. The future of these grafts will depend on the development of techniques for the neogenesis of beta cells.
ISSN: 0077-8923
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical Residents Medicine
Clinical and Experimental Endocrinology
× corresponding author
# (joint) last author

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