Title: Plasmin deficiency in Alzheimer's disease brains: causal or casual?
Authors: Dotti, Carlos ×
Galvan, C
Ledesma, MD #
Issue Date: 2004
Publisher: Karger
Series Title: Neuro-degenerative diseases vol:1 issue:4-5 pages:205-212
Abstract: Substantial recent evidence suggests that defects in amyloid peptide degradation can be at the base of cases of sporadic Alzheimer's disease (AD). Among the discovered brain enzymes with the capacity to degrade amyloid peptide, the serine protease plasmin acquires special physiological relevance because of its low levels in areas of AD human brains with a high susceptibility to amyloid plaque accumulation. In this article we comment on a series of observations supporting the fact that plasmin paucity in the brain is not simply a secondary event in the disease but rather a primary defect in certain cases of sporadic AD. We also refer to recent data pointing to alterations in raft membrane domains and diminished membrane cholesterol as the underlying cause. Finally, we discuss the possibility that plasmin deficiency in the brain could lead to AD symptomatology because of amyloid aggregation and the triggering of cell death signaling cascades. Copyright 2004 S. Karger AG, Basel.
ISSN: 1660-2854
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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