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Title: Studies on anti-HIV quinolones: New insights on the C-6 position
Authors: Massari, Serena ×
Daelemans, Dirk
Manfroni, Giuseppe
Sabatini, Stefano
Tabarrini, Oriana
Pannecouque, Christophe
Cecchetti, Violetta #
Issue Date: Jan-2009
Publisher: Pergamon-elsevier science ltd
Series Title: Bioorganic & medicinal chemistry vol:17 issue:2 pages:667-74
Abstract: The 6-desfluoroquinolones which have been developed by our group represent a promising class of compounds for the treatment of HIV infection since they act on transcriptional regulation, a crucial step in the replication cycle that has not been clinically exploited, yet. Focussing attention on the N-1 and C-6 positions, a novel series of quinolones has been synthesized. New SAR insights have been obtained, in particular, the hydroxyl group emerged as a suitable C-6 substituent when coupled with the appropriate arylpiperazine at the neighboring C-7 position. (C) 2008 Elsevier Ltd. All rights reserved.
ISSN: 0968-0896
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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