Title: Transgenic mouse model for the fragile-X syndrome
Authors: Kooy, R. Frank ×
D'Hooge, Rudi
Reyniers, Edwin
Bakker, Cathy E.
Nagels, Guy
De Boulle, Kristel
Storm, Katrien
Clincke, Gilbert
De Deyn, Peter P.
Oostra, Ben A.
Willems, Patrick J. #
Issue Date: 1996
Publisher: Wiley-Liss
Series Title: American Journal of Medical Genetics vol:64 issue:2 pages:241-245
Abstract: Transgenic fragile X knockout mice have been constructed to provide an animal model to study the physiologic function of the fragile X gene (FMR1) and to gain more insight into the clinical phenotype caused by the absence of the fragile X protein. Initial experiments suggested that the knockout mice show macroorchidism and cognitive and behavioral deficits, abnormalities comparable to those of human fragile X patients. In the present study, we have extended our experiments, and conclude that the Fmr1 knockout mouse is a reliable transgenic model to study the fragile X syndrome
ISSN: 0148-7299
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory for Biological Psychology
× corresponding author
# (joint) last author

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