Title: Mechanisms for the selective action of Vitamin D analogs
Authors: Bouillon, Roger ×
Verlinden, Lieve
Eelen, Guy
De Clercq, Pierre
Vandewalle, Maurits
Mathieu, Chantal
Verstuyf, Annemieke #
Issue Date: Oct-2005
Publisher: Pergamon Press
Series Title: Journal of Steroid Biochemistry and Molecular Biology vol:97 issue:1-2 pages:21-30
Abstract: The non-classical effects of 1,25(OH)(2)D(3) create possible therapeutic applications for immune modulation (e.g. auto-immune diseases and graft rejection), inhibition of cell proliferation (e.g. psoriasis, cancer) and induction of cell differentiation (e.g. cancer). The major drawback related to the use of 1,25(OH)(2)D(3) is its calcemic effect, which prevents the application of pharmacological concentrations. Several analogs are now available that show modest to good selectivity with regard to specific effects (e.g. anticancer or immune effects or bone anabolism versus hypercalcemia) when tested in appropriate in vivo models. The molecular basis for this selectivity is only partially understood and probably a variable mixture of mechanisms.
ISSN: 0960-0760
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical and Experimental Endocrinology
× corresponding author
# (joint) last author

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