Title: Bradykinin induces interleukin-6 and synergizes with interleukin-1
Authors: Vandekerckhove, F ×
Opdenakker, Ghislain
Van Ranst, Marc
Lenaerts, J-P
Put, W
Billiau, Alfons
Van Damme, Jozef #
Issue Date: Aug-1991
Publisher: Mary ann liebert inc publ
Series Title: Lymphokine and cytokine research vol:10 issue:4 pages:285-9
Abstract: Bradykinin was found to induce production of IL-6 in human diploid fibroblasts, as well as in a hepatoma-derived cell line, but not in a human melanoma or an osteosarcoma cell line. With the exception of the melanoma cell line, these cells were also found to be responsive to IL-1 beta. The response to bradykinin was faster but less high than that induced by IL-1. Experiments in which IL-1 (-alpha or -beta) and bradykinin were applied simultaneously revealed a synergistic interaction. Of the other cytokines tested, TNF-alpha and IFN-gamma weakly induced IL-6. Neither IL-2, IFN-alpha, nor IFN-beta was able to induce IL-6, either in the absence or the presence of bradykinin. These observations constitute further evidence for the existence of interactions between cytokine and noncytokine peptides, thus linking the neuroendocrine and immune systems.
ISSN: 0277-6766
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Molecular Immunology (Rega Institute)
Laboratory of Clinical and Epidemiological Virology (Rega Institute)
Academic Center for General Practice
Faculty of Medicine - miscellaneous
Laboratory of Immunobiology (Rega Institute)
Laboratory of Nephrology
× corresponding author
# (joint) last author

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