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Keywords:

Adolescent, Animals, Antigens, Binding, Competitive, Blood Glucose, Bone Diseases, Developmental, Bucladesine, Child, Child, Preschool, Female, Growth Hormone, Guinea Pigs, Humans, Hydrocortisone, Hypertrophy, Hypopituitarism, Immune Sera, Insulin, Male, Puberty, Precocious, Radioimmunoassay, Stimulation, Chemical, Syndrome, Science & Technology, Life Sciences & Biomedicine, Pediatrics

Abstract:

Abstract. Vanderschueren‐Lodeweyckx, M., Van den Berghe, G., Proesmans, W., Corbeel, L., Eggermont, E. and Eeckels, R. (Department of Paediatrics, Katholieke Universiteit Leuven, Belgium). Dibutyryl cyclic 3':5'‐adenosine monophosphate in hypopituitarism and Silver‐Russel syndrome. Acta Paediatr Scand 63: 364, 1974.–The effect of the infusion of dibutyryl cyclic 3':5'‐adenosine monophosphate (0.2 mg/kg/min during 1 hour) on plasma growth hormone and on glucose, immunoreactive insulin and cortisol was studied in 3 control children, in 2 Silver‐Russell patients and in 8 patients with idiopathic hypopituitarism. Upon the infusion of the cyclic nucleotide, plasma glucose and immunoreactive insulin increased markedly. An increased level of plasma cortisol was also observed in all cases except in one hypopituitary patient with associated ACTH deficiency. In contrast to what has been reported in normal subjects and observed in the 3 normal children and the 2 Silver‐Russell patients, dibutyryl cyclic 3':5'‐adenosine monophosphate failed to increase the level of plasma growth hormone above 1 ng per ml in 7 out of the 8 hypopituitary patients. Exogenous dibutyryl c‐AMP may be considered as an alternative test for the study of growth hormone release. Copyright © 1974, Wiley Blackwell. All rights reserved