Title: Ethnic variations in uterine leiomyoma biology are not caused by differences in myometrial estrogen receptor alpha levels
Authors: Amant, Frédéric ×
Huys, Erik
Geurts-Moespot, Anneke
Lindeque, B G
Vergote, Ignace
Sweep, Fred
Schoenmakers, Eric F P M #
Issue Date: Feb-2003
Series Title: Journal of the Society for Gynecologic Investigation vol:10 issue:2 pages:105-9
Abstract: OBJECTIVE: Uterine leiomyomas develop in women of reproductive age and regress after menopause, suggesting that they grow in a steroid hormone-dependent fashion. Furthermore, it is widely accepted that symptomatic uterine leiomyomas occur at a twofold to threefold higher frequency in black women than in white women. The present study was designed to investigate a possible physiologic role of racial differences in the myometrial estrogen receptor alpha in this phenomenon. METHODS: We compared the expression of the estrogen receptor and progesterone receptor in myometrium by ligand-binding assay and the estrogen receptor alpha by real-time polymerase chain reaction in women from different ethnic backgrounds who have uterine leiomyoma. RESULTS: Estrogen receptor and progesterone receptor concentrations and estrogen receptor alpha transcription levels were not statistically different between ethnic backgrounds. CONCLUSION: Neither on a transcriptional nor on a protein level were there statistically relevant differences in steroid hormone receptor levels. A causative role for these receptors in the ethnic variation of leiomyoma biology seems unlikely.
ISSN: 1071-5576
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Gynaecological Oncology
× corresponding author
# (joint) last author

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