Title: Sensory deficits in mice hypomorphic for a mammalian homologue of unc-53
Authors: Peeters, Pieter J ×
Baker, Alexis
Goris, Ilse
Daneels, Gie
Verhasselt, Peter
Luyten, Walter
Geysen, Johan J G H
Kass, Stefan U
Moechars, Dieder W E #
Issue Date: Jun-2004
Publisher: Elsevier/North Holland Biomedical Press
Series Title: Brain Research. Developmental Brain Research vol:150 issue:2 pages:89-101
Abstract: The migration of cells and the extension of cellular processes along pathways to their defined destinations are crucial in the development of higher organisms. Caenorhabditis elegans unc-53 plays an important role in cell migration and the outgrowth of cellular processes such as axons. To gain further insight into the biological function of unc53H2, a recently identified mammalian homologue of unc-53, we have generated mice carrying a mutation of unc53H2 and provide evidence that unc53H2 is involved in neuronal development and, more specifically, the development of different sensory systems. The unc53H2 hypomorphic mouse showed a general impaired acuity of several sensory systems (olfactory, auditory, visual and pain sensation) which in case of the visual system was corroborated by the morphological observation of hypoplasia of the optic nerve. We hypothesize that in analogy with its C. elegans homologue, unc53H2 may play a role in the processes of cellular outgrowth and migration.
ISSN: 0165-3806
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Section Woman - Miscellaneous (-)
Department of Pharmaceutical & Pharmacological Sciences - miscellaneous
× corresponding author
# (joint) last author

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