Title: The Addition of 4% Oxygen to the CO2 Pneumoperitoneum Does Not Decrease Dramatically Port Site Metastases
Authors: Verguts, Jasper ×
Vergote, Ignace
Amant, Frédéric
Moerman, Philippe
Koninckx, Philippe #
Issue Date: Nov-2008
Publisher: Elsevier science inc
Series Title: Journal of minimally invasive gynecology vol:15 issue:6 pages:700-703
Article number: Author reply: 775-6.
Abstract: Study Objective: Port site metastases (PSM) after laparoscopic surgery for advanced-stage ovarian carcinoma are a cause of concern, but the pathophysiology is unknown. Because CO2 pneumoperitoneum was recently demonstrated to be a cofactor in adhesion formation and tumor implantation in a laparoscopic mouse model, and because both could be prevented by the addition of 4% oxygen to the CO2 pneumoperitoneum, we wanted to test the hypothesis that PSM could be related to tumor cell hypoxia during CO, pneumoperitoneum.
ISSN: 1553-4650
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Basic Research in Gynaecology Section (-)
Gynaecological Oncology
Translational Cell & Tissue Research
× corresponding author
# (joint) last author

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