Title: Pancreatic duct cells in human islet cell preparations are a source of angiogenic cytokines interleukin-8 and vascular endothelial growth factor
Authors: Movahedi, Babak *
Gysemans, Conny *
Jacobs-Tulleneers-Thevissen, Daniel
Mathieu, Chantal
Pipeleers, Daniel # ×
Issue Date: Aug-2008
Publisher: Amer diabetes assoc
Series Title: Diabetes vol:57 issue:8 pages:2128-2136
Abstract: OBJECTIVE-Engraftment and function of human islet cell implants is considered to be dependent on their rapid and adequate revascularization. Studies with rodent islet grafts have shown that vascular endothelial growth factor (VEGF) expression by P-cells can promote this process. The present work examines whether human islet preparations produce VEGF as well as interleukin (IL)-8, another angiogenic protein, and assesses the role of contaminating duct cells in VEGF and IL-8-mediated angiogenesis.
ISSN: 0012-1797
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical and Experimental Endocrinology
Medical Clerkships Centers
* (joint) first author
× corresponding author
# (joint) last author

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