Title: IGFBP-1 Levels in Cervicovaginal Secretions before and after Amniocentesis
Authors: Devlieger, Roland ×
Verhaeghe, Johan
Coopmans, Willy
Deprest, Jan #
Issue Date: 2008
Publisher: Karger
Series Title: Gynecologic and obstetric investigation vol:67 issue:1 pages:9-13
Abstract: Background: To evaluate the levels of insulin-like growth factor-binding protein-1 (IGFBP-1) in cervicovaginal secretions before and after midtrimester amniocentesis and relate to clinical outcome. Methods: 100 consecutive amniocentesis procedures were studied. We measured the IGFBP-1 concentration by radioimmunoassay in a cervicovaginal specimen before and after mid-trimester amniocentesis. The post-amniocentesis occurrence of vaginal loss of fluid or blood and abdominal pain was assessed by questionnaire. Results: In 6 cases there was a 100-fold increase in IGFBP-1 levels after amniocentesis. Loss of fluid per vaginam occurred in 4 (67%) of these pregnancies, compared to 3.2% of pregnancies without significant surge (p < 0.0001). In addition, post-procedural abdominal pain was more common among women with increased IGFBP-1 levels after amniocentesis (50 vs. 14%, p = 0.05). Two (33%) of the 6 patients with increased IGFBP-1 after amniocentesis delivered prior to 37 weeks as a result of spontaneous preterm labor and/ or preterm ruptured membranes, compared to 7 (7%) in the group without surge in IGFBP-1 (p = 0.09). Conclusion: Increased post-procedure IGFBP-1 levels are after mid-trimester amniocenteses are related to procedure- related complications like abdominal pain and subsequent amniotic fluid leakage. Copyright (C) 2008 S. Karger AG, Basel
ISSN: 0378-7346
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Foetal Medicine Section (-)
Pathophysiology of Pregnancy Section (-)
Clinical and Experimental Endocrinology
× corresponding author
# (joint) last author

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