Title: Activity and safety of combined rituximab with chlorambucil in patients with mantle cell lymphoma
Authors: Bauwens, D ×
Maerevoet, M
Michaux, L
Theate, I
Hagemeijer-Hausman, Anne
Stul, M
Danse, E
Costantini, S
Vannuffel, P
Straetmans, N
Vekemans, MC
Deneys, V
Ferrant, A
Van Den Neste, E #
Issue Date: Nov-2005
Publisher: Blackwell publishing
Series Title: British journal of haematology vol:131 issue:3 pages:338-340
Abstract: We evaluated the combination of rituximab with chlorambucil in patients with mantle cell lymphoma (MCL) not eligible for aggressive therapy. Fourteen patients (male/female: 9/5) were included (two newly diagnosed, 12 relapsed/refractory). The toxicities were neutropenia, thrombopenia and infection. Nine (64%) patients responded; five (36%) achieved complete remission and four (29%) achieved partial remission. The median progression-free survival for responders was 26 months (95% CI, 4-48). Marrow polymerase chain reaction negativity was attained in seven responders. These results suggest that this schedule may have notable antitumour activity in patients with MCL, including patients in relapse after autologous stem cell transplantation.
ISSN: 0007-1048
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical Genetics Section (-)
× corresponding author
# (joint) last author

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