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Title: Trisomy 11 in myeloid malignancies is associated with internal tandem duplication of both MLL and FLT3 genes
Authors: Rege-Cambrin, Giovanna ×
Giugliano, Emilia
Michaux, Lucienne
Stul, Michel
Scaravaglio, Patrizia
Serra, Anna
Saglio, Giuseppe
Hagemeijer-Hausman, Anne #
Issue Date: Feb-2005
Publisher: Ferrata storti foundation
Series Title: Haematologica vol:90 issue:2 pages:262-264
Abstract: In 20 patients with myeloid malignancies and isolated trisomy 11 an internal tandem duplication of the MLL and FLT3 genes was observed in 41% and 31% of the cases, respectively; 80% of the FLT3+ cases showed MLL self-fusion. Concomitant presence of MLL and FLT3 anomalies could be relevant in determining the poor outcome of patients with acute myeloid leukemia with trisomy 11.
URI: 
ISSN: 0390-6078
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
Laboratory for Genetics of Malignant Disorders
× corresponding author
# (joint) last author

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