Title: Hydatidiform mole and triploidy: the role of genomic imprinting in placental development
Authors: Devriendt, Koenraad # ×
Issue Date: Mar-2005
Publisher: Published for the European Society of Human Reproduction and Embryology by Oxford University Press
Series Title: Human Reproduction Update vol:11 issue:2 pages:137-142
Abstract: Genomic imprinting, the differential expression of paternal and maternal alleles, is involved in the regulation of embryonic and fetal growth and development. In this review, we focus on the genetics of a disorder caused by a global defect in genomic imprinting, the hydatidiform mole. The ratio between the maternal and paternal genomes is critical in determining the development of both the embryonic and extraembryonic tissues, with an excess of paternally derived chromosomes leading to a complete (no maternal genome) or partial (lower amount of maternal chromosomes) mole. The recent identification and molecular studies in biparental complete moles may yield more insight into the regulation of imprinting during gametogenesis.
ISSN: 1355-4786
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical Genetics Section (-)
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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