Title: Association of patent ductus arteriosus and severe hypothyroidism in term newborns: coincidence or causal?
Authors: Allegaert, Karel ×
Vanhole, Christine
Van Helvoirt, Maria
Vanhaesebrouck, Sophie
Gewillig, Marc
Debeer, Anne
Devlieger, Hugo
de Zegher, Francis #
Issue Date: Dec-2004
Publisher: Parthenon Pub. Group
Series Title: Journal of Maternal-Fetal & Neonatal Medicine vol:16 issue:6 pages:339-41
Abstract: We report on 3 term newborns with the association of patent ductus arteriosus (PDA) and severe hypothyroidism attributed to thyroid agenesis (n = 2) or feto-maternal pit-1 deficiency (n = 1). This association suggests that sufficient thyroid hormone availability is among the prerequisites for normal postnatal ductal closure. Unravelling the maturational effects of thyroid hormone on the ductus arteriosus might also be relevant in preterm infants as further studies of the perinatal thyroid axis may clarify the potential role of thyroid hormone in PDA closure in preterm infants. Based on our observation, hypothyroidism should be considered in term infants with PDA.
ISSN: 1476-7058
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Section Newborn (-)
Pediatric Cardiology Section (-)
Cardiovascular Developmental Biology
× corresponding author
# (joint) last author

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