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Title: Prevention of acute autoimmune encephalomyelitis and abrogation of relapses in murine models of multiple sclerosis by the protease inhibitor D-penicillamine
Authors: Norga, Koenraad ×
Paemen, L
Masure, S
Dillen, C
Heremans, Hubertine
Billiau, Alfons
Carton, Herwig
Cuzner, L
Olsson, T
Van Damme, Jozef
Opdenakker, Ghislain #
Issue Date: Dec-1995
Series Title: Inflammation research : official journal of the European Histamine Research Society ... [et al.] vol:44 issue:12 pages:529-34
Abstract: The in vitro activity of gelatinase B, an enzyme whose appearance in the cerebrospinal fluid is associated with inflammatory diseases of the central nervous system, was dose-dependently inhibited by the antirheumatic D-penicillamine. Inhibition of gelatinase B in electrophoretically pure preparations and in cell culture supernatants and human body fluids was obtained at dosages reached in the circulation of patients treated with a peroral dosis of 750 mg D-penicillamine per day. In mice, developing acute demyelination, D-penicillamine significantly reduced the mortality and morbidity rates of experimental allergic encephalomyelitis (EAE). In chronic relapsing EAE in Biozzi AB/H mice, an animal model for relapses in multiple sclerosis (MS), it attenuated the exacerbations, even when the treatment was started after the primary full-blown disease had developed. We infer protease inhibition as the mechanism of action of D-penicillamine and suggest that its use may be effective as peroral treatment for MS.
ISSN: 1023-3830
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Immunobiology (Rega Institute)
Faculty of Medicine - miscellaneous
Academic Center for General Practice
Laboratory of Molecular Immunology (Rega Institute)
Pediatric Hematology & Oncology Section (-)
× corresponding author
# (joint) last author

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