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Title: Association between HER-2/neu and the progesterone receptor in oestrogen-dependent breast cancer is age-related
Authors: Huang, Huei-Jean ×
Neven, Patrick
Drijkoningen, Maria
Paridaens, Robert
Wildiers, Hans
Van Limbergen, Erik
Berteloot, Patrick
Amant, Frédéric
Christiaens, Marie-Rose
Vergote, Ignace #
Issue Date: May-2005
Series Title: Breast cancer research and treatment vol:91 issue:1 pages:81-87
Abstract: In oestrogen receptor-positive (ER+) breast cancer, HER-2/neu and the progesterone receptor (PR) are inversely associated. This explains a lower response to anti-oestrogens if ER+ breast cancers are HER-2/neu positive. One randomized study however, showed that premenopausal women with an ER+ breast cancer respond to anti-oestrogens independent of HER-2/neu. We therefore hypothesized an age-related association between HER-2/neu and PR in ER+ breast cancers. Receptors for ER, PR and HER-2/neu were analysed by immunohistochemistry (IHC). A uni- and multivariate analyses was carried out to assess this relationship in 1104 women with an ER+ breast cancer. We observed an inverse association between HER-2/neu and PR only after age 45. There were 173 women of age<or=45 and 931 of age>45 years. In multivariate analysis, only tumour grade (p=0.005) but not PR status was associated with HER-2/neu in women age<or=45 years. However, in age>45 years group, both PR status (p=0.001) and tumour grade (p=0.001) were independently associated with HER-2/neu. In ER+ breast cancers from women age>45, PR was positive in 76.9% if HER-2/neu negative but in 53.4% if HER-2/neu positive (p<0.001) and the median quantitative PR levels are 150 and 75 respectively in HER-2/neu negative and HER-2/neu positive tumours (p=0.002). This age effect of HER-2/neu on the PR status was not seen in women age<or=45 years and the median quantitative PR levels are 200 and 220 respectively in HER-2/neu negative and HER-2/neu positive tumours (p=0.518). The study confirms an age-related inverse relationship between HER-2/neu and PR only in women age>45 years but not in women age<or=45 years.
URI: 
ISSN: 0167-6806
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Gynaecological Oncology
Laboratory of Experimental Oncology
Laboratory of Experimental Radiotherapy
Multidisciplinary Breast Clinic Section (-)
Surgical Oncology
Interdepartmental Platform Hospital Care
× corresponding author
# (joint) last author

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