In vitro evaluation of nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 as human immunodeficiency virus microbicides
Van Herrewege, Yven Michiels, Jo Van Roey, Jens Fransen, Katrien Kestens, Luc Balzarini, Jan Lewi, Paul Vanham, Guido Janssen, Paul #
Antimicrobial Agents and Chemotherapy vol:48 issue:1 pages:337-9
The nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 (Dapivirine) effectively prevented human immunodeficiency virus (HIV) infection in cocultures of monocyte-derived dendritic cells and T cells, representing primary targets in sexual transmission. Both drugs had a favorable therapeutic index. A 24-h treatment with 1,000 nM UC-781 or 100 nM TMC120-R147681 prevented cell-free HIV infection, whereas 10-fold-higher concentrations blocked cell-associated HIV.