Title: In vitro evaluation of nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 as human immunodeficiency virus microbicides
Authors: Van Herrewege, Yven
Michiels, Jo
Van Roey, Jens
Fransen, Katrien
Kestens, Luc
Balzarini, Jan
Lewi, Paul
Vanham, Guido
Janssen, Paul #
Issue Date: Jan-2004
Series Title: Antimicrobial Agents and Chemotherapy vol:48 issue:1 pages:337-9
Abstract: The nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 (Dapivirine) effectively prevented human immunodeficiency virus (HIV) infection in cocultures of monocyte-derived dendritic cells and T cells, representing primary targets in sexual transmission. Both drugs had a favorable therapeutic index. A 24-h treatment with 1,000 nM UC-781 or 100 nM TMC120-R147681 prevented cell-free HIV infection, whereas 10-fold-higher concentrations blocked cell-associated HIV.
ISSN: 0066-4804
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
# (joint) last author

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