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Title: Novel polymorphisms in the IL-10 related AK155 gene (chromosome 12q15)
Authors: Goris, An
Marrosu, Maria Giovanna
Vandenbroeck, Koen # ×
Issue Date: Aug-2001
Publisher: Nature publishing group
Series Title: Genes and immunity vol:2 issue:5 pages:284-286
Abstract: AK155 is a recently discovered cytokine distantly related to IL-10. Its gene is located on chromosome 12q15, a region that is likely to harbour susceptibility genes for autoimmune and allergic diseases. We provide here identification and characterization of two microsatellite polymorphisms at the AK155 locus, ie D12S2511 and D12S2510. The first is located in the third intron and the second in the 3' region of the gene. Both might be useful as markers in association or linkage studies of polygenic inflammatory or allergic diseases. No association with multiple sclerosis was found for each of these markers by means of the transmission disequilibrium test in an extended number of Sardinian simplex families.
ISSN: 1466-4879
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Research Group Experimental Neurology
Laboratory for Neuroimmunology
× corresponding author
# (joint) last author

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