Title: Effect of NaCN on currents evoked by uremic retention solutes in dissociated mouse neurons
Authors: Torremans, A. ×
D'Hooge, Rudi
Van de Vijver, G.
Marescau, B.
Vanholder, R.
Lamaire, N.
De Deyn, P.P.
Van Bogaert, P.P. #
Issue Date: 2004
Publisher: Elsevier/North Holland
Series Title: Brain Research vol:1008 issue:1 pages:107-112
Abstract: Uremic retention solutes possibly contribute to neuronal hypoxia/ischemia and its consequences in patients with renal failure. We examined the in vitro effects of several uremic retention solutes on murine central neurons under chemically induced metabolic hypoxia by application of sodium cyanide (NaCN). Whole cell currents were recorded using the tight-seal whole-cell voltage clamp technique. Application of NaCN caused an inward whole-cell current. From all tested toxins, which included several indoles, guanidino compounds, polyamines, purines, phenols, DL-homocysteine, orotate and myoinositol, only creatinine (CTN), guanidine (G) and guanidinosuccinic acid (GSA) produced a significant current in control and hypoxic neurons. Current evoked by GSA was significantly increased in the chemical hypoxic condition, and a synergistic effect of GSA and spermine was observed in hypoxic neurons
ISSN: 0006-8993
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory for Biological Psychology
× corresponding author
# (joint) last author

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