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Title: T-cell mediated late increase in bronchial tone after allergen provocation in a murine asthma model
Authors: Meyts, Isabelle ×
Vanoirbeek, Jeroen
Hens, Greet
Vanaudenaerde, Bart
Verbinnen, Bert
Bullens, Dominique
Overbergh, Lutgart
Mathieu, Chantal
Ceuppens, Jan
Hellings, Peter #
Issue Date: Aug-2008
Publisher: Academic Press
Series Title: Clinical Immunology vol:128 issue:2 pages:248-258
Abstract: Allergen inhalation by sensitized asthmatics induces an IgE and mast cell dependent bronchoconstriction and a Th2-dependent inflammatory airway reaction, mucus hypersecretion and airway hyperreactivity. The link between T cells and bronchoconstriction remains controversial. Here we analyzed allergen-induced changes in airway tone in ovalbumin-sensitized mice with established allergic airway inflammation. Inhalation of nebulized ovalbumin elicited a dose-dependent and allergen-specific increase in airway resistance and bronchial tone with a concomitant increase of lymphocytes and eosinophils in bronchoalveolar lavage fluid. A Th2 pattern of cytokine expression and increased mRNA expression of MCP-1, RANTES and VCAM-1 were demonstrated. Anti-CD4 monoclonal antibody treatment prior to provocation decreased IL-13 and VCAM-1 mRNA expression and abolished the increase in bronchial tone and the inflammatory response. We conclude that allergen inhalation in sensitized mice induces airway narrowing similar to the late asthmatic reactions in humans and that this phenomenon is based on activation of CD4(+) T cells.
ISSN: 1521-6616
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical and Experimental Endocrinology
Laboratory of Clinical Immunology
Research Group Experimental Oto-rhino-laryngology
Pneumology
Occupational, Environmental and Insurance Medicine (-)
Laboratory of Pediatric Immunology
Experimental Laboratory Immunology
× corresponding author
# (joint) last author

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