Title: A hypoallergenic variant of Der p 1 as candidate for mite allergy vaccines
Authors: Walgraffe, D ×
Mattéotti, C
el Bakkoury, M
Garcia, L
Marchand, C
Bullens, Dominique
Vandenbranden, M
Jacquet, A #
Issue Date: May-2009
Publisher: Elsevier
Series Title: Journal of Allergy and Clinical Immunology vol:123 issue:5 pages:1150-1156
Abstract: Background: Recombinant hypoallergens that display reduced allergenicity but retain Tcell
reactivity represent promising candidates to improve the safety and efficacy of allergen-specific
vaccines or immunotherapy.
Objective: The present study reports the immunological characterization of a hypoallergenic variant
of the major mite allergen Der p 1.
Methods: Recombinant proform of Der p 1 (ProDer p 1) was expressed in E. coli (ProDer p 1 coli),
purified and characterized at the level of its secondary structure, IgE and T cell reactivities.
Moreover, the prophylactic potential of ProDer p 1 coli vaccinations was evaluated in a murine Der
p 1 sensitization model
ISSN: 0091-6749
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Pediatric Immunology
× corresponding author
# (joint) last author

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