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Title: CINRG randomized controlled trial of creatine and glutamine in Duchenne muscular dystrophy
Authors: Escolar, Diana M ×
Buyse, Gunnar
Henricson, Erik
Leshner, Robert
Florence, Julaine
Mayhew, Jill
Tesi-Rocha, Carolina
Gorni, Ksenija
Pasquali, Livia
Patel, Kantilal M
McCarter, Robert
Huang, Jennifer
Mayhew, Thomas
Bertorini, Tulio
Carlo, Jose
Connolly, Anne M
Clemens, Paula R
Goemans, Nathalie
Iannaccone, Susan T
Igarashi, Masanori
Nevo, Yoram
Pestronk, Alan
Subramony, S H
Vedanarayanan, V V
Wessel, Henry #
Issue Date: Jul-2005
Series Title: Annals of neurology vol:58 issue:1 pages:151-5
Abstract: We tested the efficacy and safety of glutamine (0.6 gm/kg/day) and creatine (5 gm/day) in 50 ambulant boys with Duchenne muscular dystrophy in a 6-month, double-blind, placebo-controlled clinical trial. Drug efficacy was tested by measuring muscle strength manually (34 muscle groups) and quantitatively (10 muscle groups). Timed functional tests, functional parameters, and pulmonary function tests were secondary outcome measures. Although there was no statistically significant effect of either therapy based on manual and quantitative measurements of muscle strength, a disease-modifying effect of creatine in older Duchenne muscular dystrophy and creatine and glutamine in younger Duchenne muscular dystrophy cannot be excluded. Creatine and glutamine were well tolerated.
URI: 
ISSN: 0364-5134
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Brain & Metabolism Section (-)
× corresponding author
# (joint) last author

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