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Title: A ruthenium-catalyzed approach to the Friedlander quinoline synthesis
Authors: Mierde, Hans Vander ×
Van Der Voort, Pascal
De Vos, Dirk
Verpoort, Francis #
Issue Date: Mar-2008
Publisher: Wiley-VCH
Series Title: European Journal of Organic Chemistry issue:9 pages:1625-1631
Abstract: In a modification of the Friedlander reaction, 2-aminobenzyl alcohol is oxidatively cyclized with a variety of ketones to yield substituted quinolines. Of all the ruthenium catalysts that were tested for this reaction, the second-generation Grubbs' catalyst gives the highest quinoline yield, in combination with KOtBu as a base. The presence of a hydrogen acceptor is required to regenerate the catalyst. Also the reaction mechanism is discussed, and the results show that there are possibly two different pathways towards quinolines.
ISSN: 1434-193X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Centre for Surface Chemistry and Catalysis
× corresponding author
# (joint) last author

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