Title: Uterine carcinosarcoma with melanocytic differentiation
Authors: Amant, Frédéric ×
Moerman, Philippe
Davel, G H
De Vos, Rita
Vergote, Ignace
Lindeque, B G
de Jonge, E #
Issue Date: Apr-2001
Publisher: Raven Press
Series Title: International Journal of Gynecological Pathology vol:20 issue:2 pages:186-190
Abstract: A 65-year-old black woman was found to have a 3.0 cm endometrial tumor that was a carcinosarcoma with a major epithelial and a less prominent mesenchymal component. The latter was undifferentiated but one focus of chondroid differentiation was noted. The former showed papillary serous differentiation. Melanin pigment was observed in both epithelial and mesenchymal components. Staining with antisera to S100 protein and HMB-45 confirmed the presence of melanocytes. An endocervical focus of tumor also contained melanin. Electron-microscopic studies showed large tumor cells with an irregularly indented nucleus and abnormal giant cytoplasmic melanosomes. Only one case of uterine carcinosarcoma with melanocytic differentiation has been previously reported.
ISSN: 0277-1691
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Cell & Tissue Research
Gynaecological Oncology
× corresponding author
# (joint) last author

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