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Title: Neonatal haemochromatosis
Authors: Moerman, Philippe ×
Pauwels, P
Vandenberghe, K
Devlieger, Hugo
Fryns, Jean-Pierre
Verresen, Herman
Jaeken, Jacques
Lauweryns, Jozef
Eggermont, Ephrem #
Issue Date: Oct-1990
Series Title: Histopathology vol:17 issue:4 pages:345-51
Abstract: Four cases of neonatal haemochromatosis presenting as fulminant hepatic failure in the newborn were diagnosed by autopsy. In all four cases the diagnosis was made by histochemical demonstration of excessive iron deposition in hepatocytes and extrahepatic parenchymal cells, particularly pancreatic acinar epithelium, thyroid follicular epithelium and distal renal tubules. No haemosiderin was detectable in the extrahepatic mononuclear-phagocytic cells of the spleen, lymph nodes and bone marrow. The liver was the most severely affected organ. The hepatic haemosiderosis was associated with massive hepatocellular necrosis of prenatal onset in three patients, one of whom showed formation of regenerative nodules, establishing true congenital cirrhosis. Other inconstant findings included giant cell transformation, diffuse sinusoidal fibrosis with segregation of small groups of hepatocytes and cholestasis with pseudoacinar change of liver cell plates. The fetal liver disease had its onset in the late second trimester of pregnancy and was reflected clinically by severe panhypoproteinaemia with non-immune hydrops; hyperbilirubinaemia and haemorrhagic diatheses were apparent in the newborn. Neonatal haemochromatosis is a metabolic disorder, probably of autosomal recessive inheritance. The site and nature of the basic defect remain uncertain. Pathologists should be aware of this condition and its potential recurrence in subsequent pregnancies.
ISSN: 0309-0167
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Faculty of Medicine - miscellaneous
Clinical Genetics Section (-)
Section Child - Miscellaneous (-)
Translational Cell & Tissue Research
Section Newborn (-)
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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