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Title: Tramadol concentrations in blood and in cerebrospinal fluid in a neonate
Authors: Allegaert, Karel ×
de Hoon, Jan
Verbesselt, René
Devlieger, Hugo
Tibboel, D #
Issue Date: Feb-2005
Series Title: European journal of clinical pharmacology vol:60 issue:12 pages:911-3
Abstract: Based on blood and cerebrospinal fluid samples collected in a full-term neonate, the penetration of tramadol in the central nervous system is described. Following intravenous administration of tramadol, a lag time of about 4 h was observed until full blood-brain equilibration was achieved. This pharmacokinetic observation is in line with a recent pharmacodynamic evaluation of the central opioid effects of tramadol in adults.
URI: 
ISSN: 0031-6970
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Section Newborn (-)
Clinical Pharmacology Centre (-)
× corresponding author
# (joint) last author

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