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Title: Intra-uterine Candida infection: a report of four infected fetusses from two mothers
Authors: Donders, G G ×
Moerman, Philippe
Caudron, Jozef
Van Assche, Frans Andre #
Issue Date: Feb-1991
Series Title: European Journal of Obstetrics & Gynecology and Reproductive Biology vol:38 issue:3 pages:233-8
Abstract: Although Candida albicans is a frequent inhabitant of the female genital tract, chorioamnionitis is rarely caused by this fungal organism. In this report we present two cases with manifest Candida chorioamnionitis. The first case is a twin pregnancy with premature delivery and survival of both twins. The second case is a pregnancy with intra-uterine contraceptive device in situ ending in a midtrimester abortion, followed by the next pregnancy also ending in an abortion in the second trimester. Possible triggers responsible for the increased invasiveness of otherwise benign Candida vaginitis are discussed. Foreign intra-uterine bodies such as contraceptive devices and cerclage sutures necessitate repetitive search for Candida species infection, and prompt adequate antifungal treatment in cases of documented infection. Both cases of the present report add further substantial evidence to the hypothesis of amniotic infection by ascending transcervical infection. The frequent concomitant cervical infections with other infectious agents as well as antibiotherapy influencing the normal Lactobacillary defence mechanisms are both likely to increase the risk. Systemic debilitating diseases that promote invasiveness are briefly discussed.
ISSN: 0301-2115
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Section Woman - Miscellaneous (-)
Translational Cell & Tissue Research
Faculty of Medicine - miscellaneous
× corresponding author
# (joint) last author

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