Fertility and Sterility vol:69 issue:2 pages:232-235
OBJECTIVE: To investigate the clinical characteristics of uterine myomas with cytogenetic rearrangements. DESIGN: Comparative study of myomas with normal and abnormal karyotype. SETTING: University hospital. PATIENTS: Premenopausal, GnRH-agonist (GnRH-a) treated and menopausal patients. INTERVENTIONS: Myomectomy or hysterectomy. MAIN OUTCOME MEASURES: Karyotype analysis and clinical characteristics. RESULTS: Clonal abnormalities occurred in 29% of uterine myomas but were not related to the age of the patient or, in untreated menopausal patients, to the size of the myoma. In GnRH-a treated and menopausal women, 48% of the myomas larger than 4 cm were associated with clonal abnormalities. Submucous myomas had significantly fewer clonal abnormalities (12%) than subserosal (29%) or intramural myomas (35%). CONCLUSIONS: The data support the hypothesis that cytogenetic rearrangements in uterine myomas are associated with loss of steroid hormones dependency and alter the growth potential of the tumor.