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Title: Acid, non-acid GER and gastric aspiration in lung transplant patients with or without chronic rejection
Authors: Blondeau, Kathleen ×
Mertens, Veerle
Vanaudenaerde, Bart
Verleden, Geert
Van Raemdonck, Dirk
Sifrim, Daniel
Dupont, Lieven #
Issue Date: Apr-2008
Publisher: Published jointly by the Society and Munksgaard
Series Title: European Respiratory Journal vol:31 issue:4 pages:707-713
Abstract: Acid gastroesophageal reflux (GER) and gastric aspiration have been labeled as risk factors for chronic rejection (BOS) after lung transplantation (LTx). We aimed to further characterize GER (acid and non-acid) and the degree of gastric aspiration in LTx recipients with and without BOS.Impedance-pH-recordings were used for GER detection. Pepsin and bile acids levels were measured in BALF.48% of patients had increased GER of which 27% had exclusively increased non-acid reflux. CF patients had the highest prevalence of GER. Pepsin was found in BALF of all patients and bile acids in BALF of 50% of the patients. Patients with BOS did not have increased GER or elevated pepsin in BALF. However, 70% of the patients with BOS had bile in BALF compared to 31% of stable patients. PPI treatment reduced acid reflux but did not affect non-acid reflux. Moreover, pepsin and bile levels in BALF were not reduced by PPI.Half of the LTx patients had increased reflux and non-acid reflux was common. Gastric aspiration occurred in most LTx patients. Pepsin was a more general marker and bile acids a more specific marker that might be associated with BOS. PPI treatment did not prevent non-acid reflux and gastric aspiration.
URI: 
ISSN: 0903-1936
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Thoracic Surgery
Translational Research in GastroIntestinal Disorders
Pneumology
× corresponding author
# (joint) last author

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