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Title: Long-term cognitive sequelae of antenatal maternal anxiety: involvement of the orbitofrontal cortex
Authors: Mennes, Maarten
Stiers, Peter
Lagae, Lieven
Van den Bergh, Bea # ×
Issue Date: 2006
Series Title: Neuroscience and biobehavioral reviews vol:30 issue:8 pages:1078-86
Abstract: Anxiety and stress experienced by the mother during pregnancy are reported to have a negative association with the cognitive development of the child. An integration of recent evidence from cognitive reaction time tasks pointed to a deficit in endogenous response inhibition, a function ascribed to prefrontal cortex. To further delineate the cognitive sequelae associated with antenatal maternal anxiety, we reviewed recent neuro-imaging literature to create a cortical map of regions commonly and selectively activated by well-known cognitive tasks. The pragmatic value of this cortical map was tested in a follow-up sample of 49 17-year old adolescents. Adolescents of mothers with high levels of anxiety during week 12-22 of their pregnancy performed significantly lower in tasks which required integration and control of different task parameters. Working memory, inhibition of a prepotent response, and visual orienting of attention were not impaired. Based on the established cortical map, these results were related to subtle developmental aberrations in a part of, or in cortical and sub-cortical regions linked to, the orbitofrontal cortex.
URI: 
ISSN: 0149-7634
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Section Child - Miscellaneous (-)
Laboratory for Experimental Psychology
Brain & Metabolism Section (-)
Health Psychology
× corresponding author
# (joint) last author

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