Title: FLT1 and its ligands VEGFB and PlGF: drug targets for anti-angiogenic therapy?
Authors: Fischer, Christian
Mazzone, Max
Jonckx, Bart
Carmeliet, Peter # ×
Issue Date: Dec-2008
Publisher: Nature publishing group
Series Title: Nature reviews cancer vol:8 issue:12 pages:942-956
Abstract: Less than 5 years ago, it was still not clear whether anti-angiogenic drugs would prove successful in the clinic. After numerous patients with cancer or age-related macular degeneration have been treated with these drugs, they have now become part of the standard range of therapeutic tools. Despite this milestone, anti-angiogenic therapy still faces a number of clinical hurdles, such as improving efficacy, avoiding escape and resistance, and minimizing toxicity. Hopefully, other agents with complementary mechanisms, such as those that target placental growth factor, will offer novel opportunities for improved treatment.
ISSN: 1474-175X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Vesalius Research Centre (-)
Laboratory of Tumor Inflammation and Angiogenesis (Vesalius Research Center) (+)
Laboratory of Angiogenesis and Vascular Metabolism (Vesalius Research Center) (+)
× corresponding author
# (joint) last author

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